Education

1. Post-doctoral Fellow, University of Michigan Medical School, Ann Arbor, MI (2007-2011)
2. Ph.D. in Biochemistry Miami University, Oxford, OH. ( 2007)
3. M.Sc. in Organic Chemistry in Tribhuvan University, Nepal. (1992)

Awards

• Graduate Achievement Award, Miami University, Oxford, OH 2006

Research Interests

• Biochemical Signaling
• Metalloenzymes
• Biological application of functional nanoparticles
• Structure-Function, and mechanistic studies on enzymes
• Drug/Xenobiotic metabolism

Selected Publications

1. Dong L, Sharma NP, Jurban BJ, and Smith WL. “Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer” J. Biol. Chem. (2013) 288, 28641-28655.
2. Dong L, Vecchio AJ, Sharma NP, Jurban BJ, Malkowski MG and Smith WL. “Human Cycooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer”. J. Biol. Chem. (2011) 286, 19035-46
3. Narayan P. Sharma, Liang Dong, Chong Yuan, Kathleen R Noon and William L. Smith. “Asymmetric Acetylation of the Cyclooxygenase-2 Homodimer by Aspirin and Its Effects on the Oxygenation of Arachidonic, Eicosapentaenoic and Docosahexaenoic Acids”. Mol Pharmacol (2010) 77, 979-986.
4. Gilad Rimon, Ranjinder S. Sidhu, D. Adam Lauver, Jullia Y. Lee, Narayan P. Sharma, Chong Yuan, Ryan A. Frieler, Raymond C. Trievel, Benedict R. Luchesi, and William L. Smith. “Celecoxib and other coxibs bind tightly to one monomer of cyclooxygenase-1 and interfere with the action of aspirin”. Proc. Nat. Acad. Sci. USA (2010) 107, 128-33.
5. N.Sharma, Zhenxin Hu, Michael W. Crowder and Brian Bennett “Conformational changes in the metallo-β-lactamase ImiS during the catalytic reaction: An EPR Spectrokinetic study of Co (II)-spin label interaction” J. Am. Chem. Soc.(2008) 130, 8215-8222.
6. N. P. Sharma, C. Hajdin, S. Chandrasekar, B. Benette, Ke-Wu Yang, and M.W. Crowder, “ Mechanistic studies on the mononuclear Zn(II)-containing metallo-β-lactamase ImiS from Aeromonas veronii bv. Sobria” Biochemistry (2006) 45, 10729-10738.
7. A.L. Costello, N.P. Sharma, K.W. Yang, M.W. Crowder, and D. L. Tierney, “X-ray absorption spectroscopy of the zinc binding sites in the class B2 metallo-β-lactamase ImiS from Aeromonas veronii bv. Sobria” Biochemistry (2006) 45, 13650-13658.

Teaching
Courses Developed and taught:

• Introductory Chemistry I Lecture (CHE 130T)
• Introductory Chemistry I Lab (CHE 130L)
• Introductory Chemistry II Lecture (CHE 131T)
• Introductory Chemistry II Lab (CHE 131L)
• Organic Chemistry I Lecture (CHE 230T)
• Organic Chemistry I Lab (CHE 230L)
• Organic Chemistry II Lecture (CHE 231T)
• Organic Chemistry II Lab (CHE 231L)
• Biochemistry I Lecture (CHE 430T)
• Biochemistry I Lab (CHE 430L)
• Biochemistry II Lecture

Professional Services

1. SUNY Polytechnic Institute, Utica Institute-wide Distance Learning Committee. 2021- Present
2. SUNY Polytechnic Institute, Utica Institute-wide Academic Personnel Committee. 2019 - 2020
3. SUNY Polytechnic Institute, Utica Institute-wide Curriculum Committee. 2015 - 2018
4. SUNY Polytechnic Institute, Utica Institute-wide Academic Quality Committee. 2012-2014