Biosensors

Biosensors published, “Cholesterol Chip for the Study of Cholesterol–Protein Interactions Using SPR (surface plasmon resonance),” collaborative research by Associate Professor of Nanobioscience and Director of the Redox Biology and Signal Transduction Laboratory, Dr. Ben Boivin. The research was undertaken in collaboration with researchers from Rensselaer Polytechnic Institute and Binghamton University.

The research article focuses on how “cholesterol, an important lipid in animal membranes, binds to hydrophobic pockets within many soluble proteins, transport proteins and membrane bound proteins, but the study of cholesterol–protein interactions in aqueous solutions is complicated by cholesterol’s low solubility and often requires organic co-solvents or surfactant additives.” The researchers report that the results of this study “provide a novel and reusable cholesterol SA chip, with an advantage for studying the binding kinetics for various proteins while only requiring a small amount (in the nanomolar range) of materials to obtain real-time results.”

Read the research findings here