SUNY Poly collaborative research defines how acetaminophen can impact gene regulation
SUNY Poly Interim Dean of the College of Nanoscale Science and Engineering Dr. André Melendez and SUNY Poly Ph.D. graduate Sara Evke published collaborative research with the laboratory of Dr. Tom Begley of the University at Albany, “Epitranscriptomic Reprogramming Is Required to Prevent Stress and Damage from Acetaminophen,” in Genes.
From the Abstract:
“Epitranscriptomic marks, in the form of enzyme catalyzed RNA modifications, play important gene regulatory roles in response to environmental and physiological conditions. However, little is known with respect to how acute toxic doses of pharmaceuticals influence the epitranscriptome. Here we define how acetaminophen (APAP) induces epitranscriptomic reprogramming and how the writer Alkylation Repair Homolog 8 (Alkbh8) plays a key gene regulatory role in the response.”