Ben Boivin

Ben Boivin

Ben Boivin
Associate Professor of Nanobioscience; Director of the Redox Biology and Signal Transduction Laboratory


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College of Nanoscale Science + Engineering


  • Postdoctoral Fellow, Cancer Center – Signal Transduction Program, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (2011)
  • Ph.D., Biochemistry, University of Montreal, Montreal Heart Institute, Montreal, Canada (2006)
  • B.Sc., Biochemistry, University of Montreal, Montreal, Canada (1998)

Past Professional Experience

  • Assistant Professor, Department of Medicine, University of Montreal, Montreal Heart Institute, Montreal, Canada (2015)
  • Adjunct Assistant Professor, Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada (2015)

Areas of Research

  • Protein Tyrosine Phosphatases
  • Post-Translational Modifications and Signal Transduction
  • Cardiac biochemistry and biology 
  • Cancer biochemistry and biology
  • Cardiac toxicology
  • Nanobiotechnology

Recent Honors and Awards

  • Jacques-de-Champlain Excellence Award, Heart and Stroke Foundation
  • Research Scholar Award (Junior 1), Fonds de Recherche du Quebec – Sante
  • Heart and Stroke Foundation of Canada Fellowship
  • Fonds de Recherche en Sante du Quebec Fellowship
  • Cold Spring Harbor Association Fellowship

Recent Publications

Yang, M., Haase, A.D., Huang, F.K., Coulis, G., Rivera, K.D., Dickinson, B.D., Chang, C.J., Pappin, D.J., Neubert, T.A., Hannon, G.J., Boivin, B.*, and Tonks, N.K*. (2014) Dephosphorylation of Tyrosine 393 in Argonaute 2 by Protein Tyrosine Phosphatase 1B Regulates Gene Silencing in Oncogenic RAS-Induced Senescence.Mol. Cell. 55, 782-790.
* Co-senior authors & co-corresponding authors

Boivin, B. and Tonks, N.K. (2015) PTP1B: deciphering ROS signal for gene silencing. Mol. Cell. Oncol. 2 (2): e975633-1.

Dagnell, M., Frijhoff, J., Pader, I., Paten, A., Boivin, B., Mandal, P.J., Tonks, N.K., Hellberg, C., Conrad, M., Arner, E.S.J., Östman, A. (2013) Thioredoxin-mediated selective activation of oxidized PTP1B modulates PDGF-receptor tyrosine kinase signaling. Proc. Natl Acad. Sci. U.S.A. 110, 13398-13403.

Boivin, B., Chaudary, F., Dickinson, B., Haque, A., Pero, S., Chang, C., Tonks, N.K. (2013) Receptor Protein Tyrosine Phosphatase Regulates Focal Adhesion Kinase Phosphorylation and ErbB2 Oncoprotein-Mediated Mammary Epithelial Cell Motility. J. Biol. Chem. 288, 36926-36935.

Boivin, B., Yang, M., Tonks, N.K. (2010) Targeting the Reversibly Oxidized Protein Tyrosine Phosphatase Superfamily. Sci. Signal. 3, pl2.

Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B.J., Skiba, B., Ooms, L.M., Stepto, N., Wu, B., Mitchell, C.A., Tonks, N.K., Watt, M.J., Febbraio, M.A., Crack, P.J., Andrikopoulos, S., Tiganis, T. (2009) Reactive oxygen species enhance insulin sensitivity. Cell Metab. 10, 260-272.

Juarez, J.C., Manuia, M., Burnett, M.E., Betancourt, O., Boivin, B., Shaw, D.E., Tonks, N.K., Mazar, A.P., Doñate, F. (2008) Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc. Natl Acad. Sci. U.S.A. 105, 7147-7152

Boivin, B., Zhang S, Arbiser JL, Zhang ZY, Tonks NK. (2008) A modified cysteinyl labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc. Natl Acad. Sci. U.S.A. 105, 9959-9964.

Boivin B, Chevalier D, Villeneuve LR, Rousseau E, Allen BG. (2003) Functional endothelin receptors are present on nuclei in cardiac myocytes. J. Biol. Chem. 278, 29153-29163. 

Boivin, B, Lavoie C, Vaniotis G, Baragli A, Villeneuve LR, Ethier N, Trieu P, Allen BG, Hébert TE. (2006) Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular myocytes. Cardiovasc. Res. 71, 69-78. 

Boivin, B., Vaniotis, G., Allen, B.G., and Hébert, T. (2008) G protein-coupled receptors in and on the cell nucleus: a new signalling paradigm? J. Rec Sig. Trans. 28, 15-28




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