SUNY Polytechnic Institute (SUNY Poly) Biology Major Nikita Shah recently co-authored research published in the Journal of Molecular and Cellular Cardiology Plus with a cohort of scientists from the Masonic Medical Research Institute (MMRI). Their research findings are significant as it may affect the results of heart-specific genetic studies. 

The work was one of the side projects Shah worked on during her internship at MMRI last summer, as well as part of her independent study with MMRI’s Dr. Zhiqiang Lin. 

This paper, titled “Comparative analysis of two independent Myh6-Cre transgenic mouse lines,” compares the tissue-specific expression patterns of two Myh6-Cre transgenic mouse lines, MDS Myh6-Cre and AUTR Myh6-Cre, to understand if they are suitable for heart-specific studies. By examining the activation of a reporter protein (tdTomato) in various organs, the study shows that both lines show Cre activity in the heart and testis. However, the AUTR Myh6-Cre line also shows significant irregular Cre activity in the brain, liver, and pancreas. 

This isn’t Shah’s first research paper, but she says the experience was very rewarding and motivating, as she continues to pursue future biology endeavors. 
“It makes me want to continue to do good and meaningful work,” said Shah. “I look forward to improving my skills in the research techniques. Each paper or project I work on deepens my understanding of the field and contributes to my professional development. This also emphasizes my passion for biology and research.”

To learn more about the published research, click here.