Many natural product drugs, such as Piperarborenine B (anticancer), incarvillateine (pain killing), and pauferrol A (topoisomerase II inhibitory activity) contain cyclobutane moiety with a specific stereochemistry.

The paper, “Unravelling supramolecular photocycloaddition: Cavitand-mediated reactivity of 3-(Aryl)Acrylic acids,” published in the Journal of Photochemistry and Photobiology A: Chemistry by SUNY Poly Assistant Professor of Biology Dr. Vijay Ramalingam, with researchers from the University of Nebraska at Kearney, helps to achieve these cyclobutane rings with a precise stereochemistry using the supramolecular photo-cycloaddition reactions (PCA).

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