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Research: Technology to Therapy
| Traumatic Neurodegeneration | Overview | |
| Spinal Cord Injury
Transplantable |
Neural Stem Cell Biology Neural Ribbon Encapsulation Circuitry & Signaling MEA & ePhys NMJs, ECM, Injury niche Bioinformatics (Animal models) |
Transplantation cell therapies require a robust reproducible and patient adaptable cell delivery platform for neuroprotection, cell retention, and circuitry neuro-regeneration with homotypic cells. |
| Traumatic Brain Injury-TBI | NCCIM (Microchip Sensor) Photolithography platforms High throughput multiplex detection platform |
Trauma disrupts architectures of cell-cell microenvironments and alters cytokine signaling. Multiplex tracking Informs on new pathways and biomarkers |
| Neurodegeneration and Aging | Overview | |
| Axonopathies Tauopathies |
Microfluidic Array Neuronal platform |
The complex cytoskeleton of axons- including intermediate filaments, actin and microtubules interact with binding partners and cargo to form a unique functional microarchitecture that is disrupted in neurodegenerative diseases |
| Bioelectronics | Overview | |
| Neural Circuits | SCI in vitro to in vivo therapeutic Platforms Neural Ribbons |
Encapsualted neurons and oligodendrocytes form a 3D neurotransmitter responsive network. |
| Mobile Opioid Detector | Detector/Biosensor | The mu opioid receptor (MOR) expressed in human neurons is an ideal biosensor to integrate into MEMS for mobile detection needs. |
| Computational and Neuromorphic | Overview | |
| Artificial Axon Artificial Synapse |
Computational Neuroscience Neuromorphic Hardware |
The challenge to track axonal dynamics while applying high- resolution imaging is not yet achieved. To fill gaps we generate informative mathematical models to guide experimentation and increase computational speed in neuromorphic hardware |
| Other Disease Areas & Applications | Overview | |
| Heart Disease | Nanotechnology platforms ePhys/Arrhythmias |
We use cardiomyocytes as models of human arrhythmias and cardiac diseases. |
| Diabetes | Bioprocessing Scaffolds | The ability to produce high quantity mature -islet cells is a bioprocessing challenge that may be met by combining stem cell technologies with novel cell-interacting platforms and designs. |
