Book and Selected Book Chapters

Y. Xie, Ed. The Nanobiotechnology Handbook. Boca Raton, FL: CRC Press, November 29, 2012, 692 Pages.

A. M. Unser, Y. Xie. Electrospinning of nanofibers. In: The Nanobiotechnology Handbook (Ed. Y. Xie), Boca Raton, FL: CRC Press, pp293-320, 2012.

R. Kumar, S. Smith, J. McNeilan, M. Keeton, J. Sanders, A. Talamo, C. Bowman, Y. Xie. Butterfly wing-inspired nanotechnology. In: The Nanobiotechnology Handbook (Ed. Y. Xie), Boca Raton, FL: CRC Press, pp203-222, 2012.

Selected Peer-reviewed Journal Publications

Y.I. Tian, X. Zhang, K. Torrejon, J. Danias, Y. Du, Y. Xie, “A biomimetic, stem-cell derived in vitro ocular outflow model”, Advanced Biosystems, 4:2000004 (2020). doi: 10.1002/adbi.202000004.

Y.I. Tian, X. Zhang, K. Torrejon, J. Danias, S. Gindina, A. Nayyar, Y. Du, Y. Xie. “Bioengineering approach to Schlemm’s canal-like stem cell differentiation for in vitro glaucoma drug screening”, Acta Biomaterialia, 105:203-213 (2020). doi: 10.1016/j.actbio.2020.01.033.

A. Kumar, T. Cheng, W. Song, B. Cheuk, E. Yang, L. Yang, Y. Xie, Y. Du. “Two-Step induction of trabecular meshwork cells from induced pluripotent stem cells for glaucoma”. Biochemical and Biophysical Research Communications, 529(2):411-417 (2020). doi: 10.1016/j.bbrc.2020.05.225.

T. Olmsted, C. Stigliano, A. Badri, F. Zhang, A. Williams, M.A.G. Koffas, Y. Xie, R.J. Linhardt, J. Cibelli, P.J. Horner, J.L. Paluh.  Fabrication of homotypic neural ribbons as a multiplex platform optimized for spinal cord delivery. Scientific Reports, 10:12939 (2020). doi: 10.1038/s41598-020-69274-7.

A. Nooshin, J.L. Paluh, Y. Xie, V. Saxena, S.T. Sharfstein. “Insulin production from hiPSC-derived pancreatic cells in a novel wicking matrix bioreactor”. Biotechnology and Bioengineering, 117: 2247– 2261 (2020). doi: 10.1002/bit-27359.

B. Mooney, Y.I. Tian, E. Rousseau, Y. Xie. “Understanding convergent signaling regulation in metastatic breast cancer cells using a bioengineered stem cell microenvironment”, Journal of Cancer Metastasis and Treatment, 5:19 (2019). doi: 10.20517/2394-4722.2018.93.

Y. Tian, R. Davis, M.R. Zonca Jr, J.H. Stern, S. Temple, Y. Xie. “Screening and optimization of potential injection vehicles for storage of retinal pigment epithelial stem cell before transplantation”, Journal of Tissue Engineering and Regenerative Medicine, 13 (1):76–86 (2019). doi: 10.1002/term.2770.

J.H. Stern, Y. Tian, J. Funderburgh, G. Pellegrini, K. Zhang, J. L. Goldberg, R. R. Ali, M. Young, Y. Xie, S. Temple. “Regenerating eye tissues to preserve and restore vision”, Cell Stem Cell, 22:834-849 (2018). doi: 10.1016/j.stem.2018.05.013. (Feature article and cover art)

B. Mooney, N. Abdul-Raof, Y. Tian, Y. Xie. “Restriction of Cancer Metastatic Potential Using Embryonic Stem Cells Encapsulated in Alginate Hydrogel Microstrands”, ACS Biomaterials Science & Engineering3(8):1769-1779 (2017). doi: 10.1021/acsbiomaterials.7b00237.

Y. Tian, M. R. Zonca Jr., J. Imbrogno, A. M. Unser, L. Sfakis, S. Temple, G. Belfort, Y. Xie. “Polarized, cobblestone, human retinal pigment epithelial cell maturation on a synthetic PEG matrix”, ACS Biomaterials Science & Engineering3(6):890-902 (2017). doi: 10.1021/acsbiomaterials.6b00757.

K.Y. Torrejon, E.L. Papke, J.R. Halman, M. Bergkvist, J. Danias, S.T. Sharfstein, Y. Xie, “TGFβ-2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor”, Scientific Reports6:38319 (2016). doi: 10.1038/srep38319.

K.Y. Torrejon, E.L. Papke, J.R. Halman, J. Stolwijk, C.N. Dautriche, M. Bergkvist, J. Danias, S.T. Sharfstein, Y. Xie, “Bioengineered glaucomatous 3D human trabecular meshwork as an in vitro disease model”, Biotechnology and Bioengineering, 113(6):1357-68 (2016). doi: 10.1002/bit.25899.

A.M. Unser, B. Mooney, D.T. Corr, Y.H. Tseng, Y. Xie, “3D brown adipogenesis to create "Brown-Fat-in-Microstrands"”, Biomaterials, 75:123-34 (2016). doi: 10.1016/j.biomaterials.2015.10.017.

C.N. Dautriche, Y. Tian, Y. Xie, S.T. Sharfstein, “A closer look at Schlemm's canal cell physiology: implications for biomimetics”, Journal of Functional Biomaterials, 6(3):963-85 (2015). doi: 10.3390/jfb6030963.

A.M. Unser, Y. Tian, Y. Xie, “Opportunities and challenges in three-dimensional brown adipogenesis of stem cells”, Biotechnology Advances33(6 Pt 1):962-79 (2015). doi: 10.1016/j.biotechadv.2015.07.005.

C.N. Dautriche, D. Szymanski, M. Kerr, K.Y. Torrejon, M. Bergkvist, Y. Xie, J. Danias, W.D. Stamer, S.T. Sharfstein, “A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening”, Biomaterials65:86-92 (2015). doi: 10.1016/j.biomaterials.2015.06.034.

A.D. Dias, A.M. Unser,  Y. Xie, D.B. Chrisey, D.T. Corr, “Generating size-controlled embryoid bodies using laser direct-write”, Biofabrication6(2):025007 (2014). doi: 10.1088/1758-5082/6/2/025007.

C. Dautriche, Y. Xie, S. Sharfstein, “Walking through trabecular meshwork biology:  towards engineering design of outflow physiology”, Biotechnology Advances, 32(5):971-83 (2014). doi: 10.1016/j.biotechadv.2014.04.012.

M. R. Zonca Jr, P. S. Yune, J. K. Williams, M. Gu, A. M. Unser, J. Imbrogno, G. Belfort, Y. Xie, “Enhanced stem cell pluripotency in surface-modified electrospun fibrous matrices”, Macromolecular Bioscience14(2):215-24 (2014). doi: 10.1002/mabi.201300252.

K. Y. Torrejon, D. Pu, M. Bergkvist, J. Danias, S. Sharfstein, Y. Xie, “Recreating a human trabecular meshwork outflow system on microfabricated porous structures”, Biotechnology and Bioengineering110(12):3205-3218 (2013). doi: 10.1002/bit.24977.

B. M. Mooney, N. Abdul Raof, Y. Li, Y. Xie, “Convergence of signaling pathways in stem cells and cancer”, Biotechnology Journal, 8:408-419 (2013). doi: 10.1002/biot.201200202.

M. R. Zonca Jr., P. S. Yune, C. L. Heldt, G. Belfort, Y. Xie, “High-throughput screening of substrate chemistry for embryonic stem cell attachment, expansion and maintaining pluripotency”, Macromolecular Bioscience13(2):177-190 (2013) doi: 10.1002/mabi.201200315.

M. R. Zonca Jr., Y. Xie, “Chemically modified micro- and nanostructured systems for pluripotent stem cell culture”, BioNanoScience2(4), 287-304 (2012), DOI: 10.1007/s12668-012-0052-7.

T. B Phamduy, N. Abdul Raof, N. R. Schiele, Z. Yan, D. T. Corr, Y. Huang, Y. Xie, D. B. Chrisey, “Laser direct-write of single microbeads into spatially ordered patterns”, Biofabrication4, 025006 (2012).

N. Abdul Raof, B. M. Mooney, Y. Xie, “Bioengineering embryonic stem cell microenvironments for the study of cancer research”, International Journal of Molecular Sciences12, 7662-7691 (2011) (Invited & Feature Article).

N. Abdul Raof, M. R. Padgen, A. Gracias, M. Bergkvist, Y. Xie, “One dimensional self-assembly of mouse embryonic stem cells using an array of hydrogel microstrands”, Biomaterials32(20), 4498-505 (2011).

N. Abdul Raof, W. K. Raja, J. Castracane, Y. Xie, “Bioengineering embryonic stem cell microenvironments for exploring inhibitory effects on metastatic breast cancer cells”, Biomaterials32(17), 4130-9 (2011).

N. Abdul Raof, N. R. Schiele, Y. Xie, D. B. Chrisey, D. T. Corr, “The maintenance of pluripotency following laser direct-write of mouse embryonic stem cells”, Biomaterials32(7), 1802-1808 (2011).

N. R. Schiele, D. T. Corr, Y. Huang, N. Abdul Raof, Y. Xie, D. B. Chrisey, “Laser-based direct-write techniques for cell printing”, Biofabrication2(3), 032001 (2010).

D. A. Soscia, N. Abdul Raof, Y. Xie, N. C. Cady, A. P. Gadre, “Antibiotic-loaded PLGA nanofibers for wound healing applications”, Advanced Engineering Materials12(4), B83-B88 (2010).

Y. Xie, J. Castracane, “High voltage electric field driven micro-/nanofabrication of polymeric drug delivery systems”, IEEE Engineering in Medicine and Biology Magazine, 28(1), 23-30 (2009).

Selected Patents

Y. Xie, M. Jorgensen, S. C. R. Kollampolly. “Devices and methods for producing tubular systems useful in cell culture”. U.S. Provisional Patent Application, filed on January 21, 2020.

Y. Xie, K. Torrejon, S. Sharfstein, M. Bergkvist, I. Danias, C. N. Dautriche. “Use of vascular cells to create the conventional outflow tract”. United States Patent Application 16/044806, filed on July 25, 2018.

Y. Xie, K. Torrejon, S. Sharfstein, M. Bergkvist, I. Danias, C. N. Dautriche. “Use of vascular cells to create the conventional outflow tract”. International Application No. PCT/IB2017/051424, filed on October 3, 2017.

M. Bergkvist, Sara A. Brenner, J. Danias, Susan Sharfstein, Y. Xie. “Bioengineered human trabecular meshwork for biological applications”. Patent Application #: US 13/771,007. Grant No. US9506907B2, granted on November 29, 2016.


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