Nature Cell Biology: Phenotypic heterogeneity of disseminated
tumour cells is preset by primary tumour hypoxic microenvironments
Published:
Monday, January 23, 2017 - 15:34
Nature Cell Biology
Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we report that hypoxic HNSCC and breast primary tumour microenvironments displayed upregulation of key dormancy (NR2F1, DEC2, p27) and hypoxia (GLUT1, HIF1α) genes.
