“We want to understand the function and the regulation of the protein tyrosine phosphatase family members in diseases such as cardiac hypertrophy, diabetes and cancer with the ultimate goal of activating or inhibiting specific PTPs to prevent or cure these diseases.”

- Ben Boivin, Director of the Redox Biology and Signal Transduction Laboratory

Research projects:

1. Understanding the oxidation mechanisms that control Protein Tyrosine Phosphatase activity in vivo
2. Allosteric-site mediated activation of Protein Tyrosine Phosphatase
3. Understanding the molecular function of PTP1B in cardiac hypertrophy
4. Understanding the molecular function of PTPs in insulin resistance
5. Understanding the function of cholesterol in redox signaling